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Causes & Risk Factors
The exact causes behind Alzheimer's Disease are yet to be identified, however, age is considered one of the most important factors with risk of the disease doubling every 5 years beyond the age of 65. (9)
Most cases of Alzheimer’s disease are due to a “...variety
of factors acting together,” with the exception of familial
Alzheimer’s disease (FAD), wherein mutations on a single gene areconsidered
the principal cause.
“Mutations in the genes that encode APPs and the presenilins can cause Alzheimer’s disease.” (9)
Other factors to note is that acetylcholine, serotonin, somatostatin, and noradrenalin reach below normal levels in people suffering from AD. Acetylcholine is an important neurotransmitter and found in abundance in the nerve cells of hippocampus and cerebral cortex -the regions affected by Alzheimer’s disease.
In addition, studies also show that people who suffer traumatic head injuries, and women are more at risk of suffering from the disease. (2) High blood pressure and cholesterol and poorly controlled diabetes are also some of the contributing risk factors to Alzheimer's Disease (10).
Article by Kona Vishnu, MS
Page Covers: What are the causes of Alzheimer's Disease?
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